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KMID : 0043319920150040379
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Archives of Pharmacal Research
1992 Volume.15 No. 4 p.379 ~ p.381
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Immunostimulating Activity of Phellinus linteus Extracts to B-lymphocyte
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Oh GT
Han SB/Kim HM/Han MW/Yoo ID
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Abstract
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Phellinus linteus was examined on its immunostimulating activities using an in vitro immunization and plaque forming cell assay. When lymphocytes were exposed to the extract of Phellinus linteus. The number of antibody forming cell was increased. In in virto plaque forming cell assay. The immunostimulating effect was about 4.8 and 5.0 times of unimmunized control in polyclonal and T-independent antibody response, respectively. Especially, Phellinus linteus significantly increased the antigenicity of TNP-LPS used as T-independent antigen. But Phellinus linteus did not show a mitogenic effect on B-lymphocytes. These results suggest that immunostimulting activity of Phillinus linteus might be associated with a functional stimulation of B-lymphocyte involved in humoral immune responses.
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